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Test Code TIUCR Titanium/Creatinine Ratio, Random, Urine


Shipping Instructions


Ship specimen on ice



Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, the specimen should not be collected for at least 96 hours.

Supplies: Urine Tubes, 10 mL (T068)

Collection Container/Tube: Clean, plastic urine collection container

Submission Container/Tube: Plastic, 10-mL urine tube or a clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 7 mL

Collection Instructions:

1. Collect a random urine specimen.

2. See Metals Analysis Specimen Collection and Transport for complete instructions.


Secondary ID

614614

Useful For

Monitoring exposure and elimination of titanium

Profile Information

Test ID Reporting Name Available Separately Always Performed
TICU Titanium/Creat Ratio, U No Yes
CRTFR Creatinine, Random, U No Yes

Method Name

TICU: Triple-Quadrupole Inductively Coupled Plasma-Mass Spectrometry (ICP-MS/MS)

CRTFR: Enzymatic Colorimetric Assay

Specimen Type

Urine

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen 28 days

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

TITANIUM

0-17 years: Not established

≥18 years: <0.4 mcg/g creatinine

 

CREATININE

≥18 years old: 16-326 mg/dL

Reference values have not been established for patients who are less than 18 years of age.

Interpretation

Elevated concentrations of urinary titanium have been reported after documented exposures.

Method Description

Titanium:

Titanium in urine is analyzed by inductively coupled plasma triple-quadrupole mass spectrometry in mass shift mode using ammonia as a reaction gas, gallium as an internal standard, and a salt matrix calibration.(Unpublished Mayo method)

 

Creatinine:

The enzymatic method is based on the determination of sarcosine from creatinine with the aid of creatininase, creatinase, and sarcosine oxidase. The liberated hydrogen peroxide is measured via a modified Trinder reaction using a colorimetric indicator. Optimization of the buffer system and the colorimetric indicator enables the creatinine concentration to be quantified both precisely and specifically. (Package insert: Creatinine plus ver 2. Roche Diagnostics; V15.0, 03/2019)

Day(s) Performed

Wednesday

Report Available

1 to 7 days

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82570

83018

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TIUCR Titanium/Creat Ratio, Random, U 104656-4

 

Result ID Test Result Name Result LOINC Value
CRTFR Creatinine, Random, U 2161-8
614615 Titanium/Creat Ratio, U 104656-4