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Test Code OXYMS Oxymorphone and Metabolite, Serum


Ordering Guidance


This test should only be ordered by healthcare professionals to monitor patients who have been prescribed oxymorphone.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (Serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL serum

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Secondary ID

623460

Useful For

Monitoring therapeutic efficacy/compliance in serum specimens of patients who are prescribed oxymorphone

 

Detection and quantification of oxymorphone and noroxymorphone in serum

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Specimen Type

Serum Red

Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 14 days
  Frozen  28 days
  Ambient  24 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Reference Values

Therapeutic range/Metabolite information (as applicable)

Oxymorphone: 1.0-8.0 ng/mL

Noroxymorphone: Metabolite of oxymorphone

 

Cutoff concentrations:

Oxymorphone: 1.0 ng/mL

Noroxymorphone: 1.0 ng/mL

Interpretation

Clinically, the presence of oxymorphone and/or noroxymorphone in serum can be used to verify adherence or compliance to prescribed opioids, and discourage drug misuse, abuse, and diversion.

 

The following adult therapeutic range is suggested by literature but must be interpreted alongside other clinical features/test results, symptoms, collection time since last dosage was taken, and signs of abuse/misuse.

Oxymorphone: 1.0-8.0 ng/mL when used as sole therapy; it is also a metabolite of oxycodone

Noroxymorphone: Not established, it is a metabolite of oxymorphone.

Method Description

The opiates are extracted from serum using a solvent to precipitate proteins. The supernatant is removed and analyzed by liquid chromatography tandem mass spectrometry.(Unpublished Mayo method)

Day(s) Performed

Tuesday

Report Available

2 to 9 days

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

G0480

80365 (if appropriate for select payers)

Clinical Toxicology CPT Code Client Guidance

LOINC Code Information

Test ID Test Order Name Order LOINC Value
OXYMS Oxymorphone and metabolite, S In Process

 

Result ID Test Result Name Result LOINC Value
623460 Oxymorphone - Free 46974-2
623461 Noroxymorphone - Free In Process