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HelpTest Code LAB9454 Posaconazole, Serum
Additional Codes
POSA
Useful For
Monitoring posaconazole therapy
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions: Within 2 hours of collection, centrifuge, and aliquot serum into plastic vial.
Specimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reference Values
>700 ng/mL (trough)
Day(s) Performed
Monday through Saturday
CPT Code Information
80187
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| POSA | Posaconazole, S | 53731-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 89591 | Posaconazole, S | 53731-6 |
Interpretation
Levels greater than 700 ng/mL (0.7 mcg/mL) have been suggested for prophylaxis.
Levels greater than or equal to 1250 ng/mL (1.25 mcg/mL) were shown to be optimal in a salvage trial for treatment of invasive Aspergillus infections.
A toxic range has not been established.
Method Description
Posaconazole is extracted by mixing serum samples with acetonitrile to precipitate proteins. The supernatant is removed and analyzed by a liquid chromatography tandem mass spectrometry method.(Unpublished Mayo method)
Report Available
2 to 5 daysSpecimen Retention Time
2 weeksReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.