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Specimen Collection Guidelines

Blood Draw Laboratories at MUSC

MUSC Requisitions and Supply Requests

Lab Supply Requests

Mayo Clinic Laboratories

Test Code LAB8976 Interleukin-2 Receptor Alpha soluble, Plasma

Additional Codes

SIL2R


Ordering Guidance


If this test is ordered with CYPAN / Cytokine Panel, Plasma, this test will be canceled as duplicate and CYPAN performed as ordered.

 

If this test is ordered with CYTH1 / T-Helper Cell Type 1 Cytokine Panel, Plasma, this test will be canceled as duplicate and CYTH1 performed as ordered.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Lavender-top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Immediately after specimen collection, place tube on wet ice.

2. Centrifuge at 4° C, 1500 x g for 10 minutes.

3. Aliquot plasma into plastic vial.

4. Freeze specimen within 2 hours of collection.

Additional Information:

If a refrigerated centrifuge is not available, it is acceptable to use a room temperature centrifuge, provided the sample is kept on ice before centrifugation and is frozen immediately afterward.


Secondary ID

622328

Useful For

Measuring the concentration of soluble interleukin-2 receptor alpha (sIL-2r alpha) in plasma

 

Aids in the diagnosis and evaluation of patients for lymphoproliferative disorders, including autoimmune lymphoproliferative syndrome, hemophagocytic lymphohistiocytosis, and macrophage activation syndrome

 

May help monitor patients with sarcoidosis or hematologic malignancies with elevated sIL-2r alpha

Method Name

Bead-Based Multiplex Immunoassay

Specimen Type

Plasma EDTA

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen 21 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject
Heat-treated specimen Reject

Reference Values

<18 years: Not established

≥18 years: <959 pg/mL

Interpretation

A significant elevation in soluble interleukin-2 receptor alpha (sIL-2r alpha) concentration (2SD above age-adjusted laboratory-specific reference range) is one of the diagnostic criteria for hemophagocytic lymphohistiocytosis (HLH) syndrome. The diagnosis of HLH syndrome should be based on compatible clinical presentation in the context of significantly elevated inflammatory markers, including ferritin, sIL-2r alpha, and CXCL9 (C-X-C motif chemokine ligand 9).

Method Description

Testing for soluble IL-2 receptor alpha (sIL-2r alpha) in plasma is performed using a laboratory-developed immunoassay.(Unpublished Mayo method)

Day(s) Performed

Thursday

Report Available

2 to 8 days

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83520

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SIL2R IL-2 receptor alpha soluble, P 76039-7

 

Result ID Test Result Name Result LOINC Value
622328 IL-2 receptor alpha soluble 76039-7