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HelpTest Code LAB8677 Hydroxychloroquine, Serum
Additional Codes
HCQ
Plaquenil
Useful For
Monitoring serum hydroxychloroquine concentrations, assessing compliance, and adjusting dosage in patients
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Specimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (gel tubes/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Collect specimen immediately before next scheduled dose.
2. Within 2 hours of collection, centrifuge, and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 21 days |
On-campus collections: Tube to 99 or deliver to University Extension Hospital Room EH318
Submission Container/Tube: Plastic vial, Refrigerated
Gel tubes/SST tubes are NOT acceptable!
Off-campus collections:
Centrifuge and aliquot within 2 hours.
Specimen to be stored/transported at Refrigerated temp.
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
For suppressive treatment of malaria, suggested plasma or serum concentrations should be >10 ng/mL.
For systemic lupus erythematosus, proposed serum target concentrations should be ≥500 ng/mL.
Interpretation
The serum concentration should be interpreted in the context of the patient's clinical response and may provide useful information in patients showing poor response, noncompliance, or adverse effects. Concentrations less than 106 ng/mL have been associated with noncompliance.
Method Description
Samples are extracted with analyte detection by tandem mass spectrometry.(Unpublished Mayo method)
Report Available
3 to 7 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
80220
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HCQ | Hydroxychloroquine, S | 3684-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 64947 | Hydroxychloroquine, S | 3684-8 |
Day(s) Performed
Monday, Wednesday, Friday
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.