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Test Code LAB800 Parvovirus B19 Antibodies, IgG and IgM, Serum

Additional Codes

PARVS


Ordering Guidance


This test is intended for patients with at least 7 days of symptoms or asymptomatic individuals with recent exposure to parvovirus B19.

 

For patients with acute, symptomatic presentation, order either PARVP / Parvovirus B19, Molecular Detection, PCR, Plasma or PARVO / Parvovirus B19, Molecular Detection, PCR, Varies.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Information: Centrifuge and aliquot serum into a plastic vial.


Secondary ID

48395

Useful For

Serologic detection of recent or past parvovirus B19 infection

Profile Information

Test ID Reporting Name Available Separately Always Performed
PARVG Parvovirus B19 Ab, IgG, S No Yes
PARVM Parvovirus B19 Ab, IgM, S No Yes
PARVN Parvovirus B19 Ab Interpretation No Yes

Method Name

PARVG, PARVM: Enzyme Immunoassay (EIA)

PARVN: Technical Interpretation

Specimen Type

Serum

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject
Heat-inactivated specimen Reject

Reference Values

IgG: Negative

IgM: Negative

Interpretation

Parvovirus B19 IgM

Parvovirus B19 IgG

Interpretation

Negative

Negative

No antibody to Parvovirus B19 detected. Acute infection cannot be ruled out as antibody levels may be below the limit of detection. If clinically indicated, a second serum should be submitted in 14 to 21 days.

Negative

Positive

Results suggest past infection.

Equivocal

Positive or negative

Recommend follow-up testing in 10 to 14 days if clinically indicated.

Positive

Positive, negative, or equivocal

Results suggest recent infection and should be interpreted in the context of clinical presentation.

 

The presence of IgM class antibodies suggests recent infection. The presence of IgG antibodies only is indicative of past exposure.

 

Both IgG and IgM may be present at or soon after onset of illness and reach peak titers within 30 days. Because IgG antibody may persist for years, diagnosis of acute infection is made by the detection of IgM antibodies.

Method Description

Antibody to parvovirus B19 is detected by a sandwich enzyme immunoassay for the detection of IgG or IgM class antibodies in serum or plasma. Specific parvovirus B19 antibodies in specimens bind to antigen-coated microtiter wells. Following a wash step, peroxidase-labeled rabbit-antihuman IgG is added that binds to parvovirus antibody. The antigen-antibody complex is detected by the addition of substrate, which turns blue in the presence of the enzyme peroxidase.(Anderson LJ, Tsou R, Parker RA, et al: Detection of antibodies and antigens of human parvovirus B19 by enzyme-linked immunosorbent assay. J Clin Microbiol. 198624[4]:522-526; Package insert: Parvovirus B19 IgG and IgM Enzyme Immunoassay. DiaSorin; 06/2019)

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 3 days

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86747 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PARVS Parvovirus B19 Ab, IgG and IgM, S 34950-6

 

Result ID Test Result Name Result LOINC Value
PARVG Parvovirus B19 Ab, IgG, S 29660-8
PARVM Parvovirus B19 Ab, IgM, S 40658-7
PARVN Parvovirus B19 Ab Interpretation 58737-8

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.