Test Code LAB7523 Manganese, Serum
Additional Codes
MNS
Useful For
Monitoring manganese exposure using serum specimens
Nutritional monitoring
Performing Laboratory
Mayo Clinic Laboratories in RochesterSpecimen Type
SerumSpecimen Required
Patient Preparation: High concentrations of gadolinium, iodine, and barium are known to interfere with most metal tests. If gadolinium-, iodine, or barium-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Metal Free Specimen Vial (T173)
Collection Container/Tube: Plain, royal blue-top Vacutainer plastic trace element blood collection tube
Submission Container/Tube: 7-mL Mayo metal-free, screw-capped, polypropylene vial
Specimen Volume: 0.3 mL
Collection Instructions:
1. Allow the specimen to clot for 30 minutes, and then centrifuge to separate serum from the cellular fraction. Serum must be removed from cellular fraction within 4 hours of collection. Avoid hemolysis.
2. Remove the stopper. Carefully pour specimen into a Mayo metal-free, polypropylene vial, while avoiding transfer of the cellular components of blood. Do not insert a pipet into the serum to accomplish transfer, and do not ream the specimen with a wooden stick to assist with serum transfer.
3. See Metals Analysis Specimen Collection and Transport for complete instructions.
Specimen Minimum Volume
0.2 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 28 days | METAL FREE |
Ambient | 28 days | METAL FREE | |
Frozen | 28 days | METAL FREE |
Special Instructions
Reference Values
0-17 years: Not established
≥18 years: 0.5-1.2 ng/mL
Day(s) Performed
Tuesday
CPT Code Information
83785
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
MNS | Manganese, S | 5683-8 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
8413 | Manganese, S | 5683-8 |
Interpretation
Serum manganese results above the reference values suggest recent exposure. Serum concentrations in combination with brain magnetic resonance imaging scans and neurological assessment may be used to detect excessive exposure.
Method Description
The metal of interest is analyzed by triple-quadrupole inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
Report Available
2 to 8 daysSpecimen Retention Time
14 daysReject Due To
Gross hemolysis | Reject |
Gross lipemia | OK |
Gross icterus | OK |
Method Name
Triple-Quadrupole Inductively Coupled Plasma-Mass Spectrometry (ICP-MS/MS)