Home
HelpTest Code LAB504 Zonisamide, Serum
Additional Codes
ZONI
Useful For
Monitoring zonisamide therapy; recommended for all patients to ensure appropriate dosing
Assessing medication compliance
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST is not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
On-campus collections: Tube to 99 or deliver to University Extension Hospital Room EH318
Submission Container/Tube: Plastic vial, Refrigerated
Off-campus collections:
Centrifuge and aliquot within 2 hours.
Specimen to be stored/transported Refrigerated
Reference Values
10-40 mcg/mL
Day(s) Performed
Monday through Saturday
CPT Code Information
80203
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ZONI | Zonisamide, S | 29620-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 83685 | Zonisamide, S | 29620-2 |
Interpretation
Steady-state zonisamide concentration in a trough specimen collected just before next dose correlates with patient response but not with dose. Optimal response to zonisamide occurs when trough zonisamide concentration is in the range of 10 to 40 mcg/mL. Peak serum concentration for zonisamide occurs 2 to 6 hours after dose, and time to peak is affected by food intake.
Because carbamazepine activates glucuronidation, patients taking carbamazepine concomitantly with zonisamide have significantly lower zonisamide concentrations compared to patients on the same dose not receiving carbamazepine.
Method Description
The serum sample is deproteinated with acetonitrile containing the deuterium labeled internal standard. The protein precipitate is centrifuged, and a portion of the supernatant is diluted with mobile phase for detection by tandem mass spectrometry.(Unpublished Mayo method)
Report Available
Same day/1 to 5 daysSpecimen Retention Time
14 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Secondary ID
83685Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Neurology Specialty Testing Client Test Request (T732)
-Therapeutics Test Request (T831)