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HelpTest Code LAB484 Oxcarbazepine Metabolite, Serum
Additional Codes
OXCARBAZEPINE LEVEL (OMHC)
Useful For
Monitoring serum concentration during oxcarbazepine therapy
Assessing compliance
Assessing potential toxicity
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST is not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Collect specimen immediately before next scheduled dose.
2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
On-campus collections: Tube to 99 or deliver to University Extension Hospital Room EH318. Submission Container/Tube: Plastic via, Refrigerated.
Off-campus collections: Centrifuge and aliquot within 2 hours. Specimen to be stored/transported Refrigerated.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reference Values
Oxcarbazepine metabolite: 10-35 mcg/mL
Day(s) Performed
Monday through Saturday
CPT Code Information
80183
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| OMHC | Oxcarbazepine Metabolite (MHC), S | 31019-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81030 | Oxcarbazepine Metabolite (MHC), S | 31019-3 |
Interpretation
Therapeutic ranges are based on specimens collected at trough (ie, immediately before the next dose). Most individuals display optimal response to oxcarbazepine therapy when serum levels of the metabolite (measured in this assay) are between 10 and 35 mcg/mL. Some individuals may respond well outside of this range or may display toxicity within the therapeutic range. Thus, interpretation should include clinical evaluation.
Method Description
The serum sample is diluted in acetonitrile containing internal standard. The protein precipitate is centrifuged, and a portion of the supernatant is diluted with mobile phase for detection by a tandem mass spectrophotometer.(Unpublished Mayo method)
Report Available
1 to 3 daysSpecimen Retention Time
14 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
High-Turbulence Liquid Chromatography Mass Spectrometry (HTLC-MS/MS)
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Neurology Specialty Testing Client Test Request (T732)
-Therapeutics Test Request (T831)