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HelpTest Code LAB477 Levetiracetam, Serum
Additional Codes
LEVE
Useful For
Monitoring serum concentration of levetiracetam, particularly in patients with kidney disease
Assessing compliance with levetiracetam therapy
Assessing potential toxicity of levetiracetam
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Supplies: Sarstedt Aliquot Tube 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Draw blood immediately before next scheduled dose.
2. For sustained-release formulations only, draw blood a minimum of 12 hours after last dose.
3. Within 2 hours of collection, centrifuge, and aliquot serum into a plastic vial
On-campus collections: Tube to 99 or deliver to University Extension Hospital Room EH318. Submission Container/Tube: Plastic vial, Refrigerated.
Off-campus collections: Centrifuge and aliquot within 2 hours. Specimen to be stored/transported Refrigerated.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reference Values
10.0-40.0 mcg/mL
Day(s) Performed
Monday through Sunday
CPT Code Information
80177
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| LEVE | Levetiracetam, S | 30471-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 83140 | Levetiracetam, S | 30471-7 |
Interpretation
Most individuals display optimal response to levetiracetam with serum levels 10.0 to 40.0 mcg/mL. Some individuals may respond well outside of this range or may display toxicity within the therapeutic range; thus, interpretation should include clinical evaluation.
Toxic levels have not been well established. Therapeutic ranges are based on specimen collected at trough (ie, immediately before the next dose).
Method Description
The serum sample is diluted in acetonitrile containing internal standard. The protein precipitate is centrifuged, and a portion of the supernatant is diluted with mobile phase for detection by a tandem mass spectrometer.(Unpublished Mayo method)
Report Available
Same day/1 to 2 daysSpecimen Retention Time
14 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Neurology Specialty Testing Client Test Request (T732)
-General Request (T239)
-Therapeutics Test Request (T831)