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HelpTest Code LAB2525 Copper, 24 Hour, Urine
Additional Codes
CUU
Useful For
Investigation of Wilson disease and obstructive liver disease using a 24-hour urine specimen
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
UrineNecessary Information
24-Hour volume (in milliliters) is required.
Specimen Required
Patient Preparation: High concentrations of barium are known to interfere with this test. If barium-containing contrast media has been administered, the specimen should not be collected for at least 96 hours.
Supplies: Urine Tubes, 10 mL (T068)
Collection Container/Tube: Clean, plastic urine collection container with no metal cap or glued insert
Submission Container/Tube: Plastic urine tube or clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 10 mL
Collection Instructions:
1. Collect urine for 24 hours.
2. Refrigerate specimen within 4 hours of completion of 24-hour collection.
3. See Metals Analysis Specimen Collection and Transport for complete instructions.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Special Instructions
Reference Values
0-17 years: Not established
≥18 years: 9-71 mcg/24 h
Day(s) Performed
Monday, Thursday
CPT Code Information
82525
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CUU | Copper, 24 Hr, U | 5633-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8590 | Copper, 24 Hr, U | 5633-3 |
| TM7 | Collection Duration | 13362-9 |
| VL4 | Urine Volume | 3167-4 |
Interpretation
Humans normally excrete less than 60 mcg/day of copper in the urine.
Urinary copper excretion greater than 60 mcg/day may be seen in:
-Wilson disease
-Obstructive biliary disease (eg, primary biliary cirrhosis, primary sclerosing cholangitis)
-Nephrotic syndrome (due to leakage through the kidney)
-Chelation therapy
-Estrogen therapy
-Mega dosing of zinc-containing vitamins
Because ceruloplasmin is an acute phase reactant, urine copper is elevated during acute inflammation. During the recovery phase, urine copper is usually below normal, reflecting the expected physiologic response to replace the copper that was depleted during inflammation.
Method Description
The metal of interest is analyzed by triple-quadrupole inductively-coupled plasma mass spectrometry.(Unpublished Mayo method)
Report Available
2 to 5 daysSpecimen Retention Time
14 daysReject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Method Name
Triple-Quadrupole Inductively-Coupled Plasma-Mass Spectrometry (ICP-MS/MS)
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen: