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HelpTest Code LAB2189 Alpha-1-Antitrypsin Phenotype, Serum
Additional Codes
A1APP
Useful For
Identification of homozygous and heterozygous phenotypes of the alpha-1-antitrypsin deficiency
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| A1AP2 | Alpha-1-Antitrypsin Phenotype | No | Yes |
| AATP | Alpha-1-Antitrypsin, S | Yes, (Order AAT) | Yes |
Testing Algorithm
See Alpha-1-Antitrypsin-A Comprehensive Testing Algorithm in Special Instructions.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1.25 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Special Instructions
Reference Values
ALPHA-1-ANTITRYPSIN
100-190 mg/dL
ALPHA-1-ANTITRYPSIN PHENOTYPE
The interpretive report will identify the alleles present. For rare alleles, the report will indicate whether or not they have been associated with reduced quantitative levels of alpha-1-antitrypsin.
Day(s) Performed
Monday through Friday
CPT Code Information
82103
82104
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| A1APP | Alpha-1-Antitrypsin Phenotype | 32769-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| AATP | Alpha-1-Antitrypsin, S | 6771-0 |
| 8166 | Alpha-1-Antitrypsin Phenotype | 32769-2 |
Interpretation
There are greater than 40 alpha-1-antitrypsin (A1A) phenotypes (most of these are associated with normal quantitative levels of protein). The most common normal phenotype is M (M, M1, or M2), and greater than 90% of individuals of European descent are genetically homozygous M (MM).
A1A deficiency is usually associated with the Z phenotype (homozygous ZZ), but SS and SZ are also associated with decreased A1A levels.
Method Description
Phenotyping is done by isoelectric focusing in agarose gels.(Package insert: Hydragel 18 A1AT Isofocusing. Sebia. 2013 July)
Nephelometry.(Instruction manual: Siemens Nephelometer II. Siemens, Inc., Newark, DE)
Report Available
2 to 6 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
Method Name
A1AP2: Isoelectric Focusing
AATP: Nephelometry
Secondary ID
26953Forms
If not ordering electronically, complete, print, and send 1 of the following with the specimen:
-Gastroenterology and Hepatology Test Request (T728)
-General Request (T239)