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Test Code LAB2184 Angiotensin Converting Enzyme, Serum

Additional Codes

ACE

Useful For

Evaluation of patients with suspected sarcoidosis

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Necessary Information


The use of angiotensin converting enzyme (ACE)-inhibiting antihypertensive drugs will cause decreased ACE values. Patients taking ACE inhibitors, such as captopril and enalapril, will have extremely low or unmeasurable ACE activity. Indicate on the request form if the patient is on ACE inhibitors.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  180 days
  Ambient  24 hours

Reference Values

≥18 years: 16-85 U/L

0-17 years: Angiotensin converting enzyme activity may be 20-50% higher in healthy children compared to healthy adults.

 

For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Day(s) Performed

Monday through Friday

CPT Code Information

82164

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ACE Angiotensin Converting Enzyme, S 2742-5

 

Result ID Test Result Name Result LOINC Value
ACE Angiotensin Converting Enzyme, S 2742-5

Interpretation

An elevation in the level of serum angiotensin converting enzyme (ACE), along with radiographic evidence of infiltrates or adenopathy and organ biopsies showing noncaseating epithelial granulomas is suggestive of a diagnosis of sarcoidosis.

 

Normal, healthy children and infants are known to have ACE activity levels greater than the adult reference interval.

Method Description

Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to angiotensin II. The enzyme also mediates the cleavage of the synthetic substrate N-(3-[2-furyl]acryloyl)-L-phenylalanylglycylglycine (FAPGG) into an amino acid derivative and a dipeptide. The kinetic of this cleavage reaction is measured by recording the decrease in absorbance at 340 nm.(Package insert: Buhlmann ACE Kinetic; 01/2013)

Report Available

1 to 3 days

Specimen Retention Time

7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Method Name

Spectrophotometry (SP)

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-General Request (T239)

-Cardiovascular Test Request (T724)

Secondary ID

603622