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Test Code LAB2125 Vanillymandelic Acid and Homovanillic Acid, Urine

Additional Codes

ARUP #0080470

Collection:

Patient Preparation
Abstain from medications for 72 hours prior to collection.
 Collect
24-hour or random urine. Refrigerate 24-hour specimen during collection.
 Specimen Preparation
Transfer 4 mL aliquot from a well mixed 24-hour urine container or a sterile cup.
 Collect random samples in a sterile cup,

Samples will be rejected if received in the BD urine culture tube or a tiger top UA tube.
Min Volume: 1.0 mL Please note on aliquot tube 24 hour collection volume or random sample.

Reference Range:

  Creatinine, Urine - per 24h
Age Male (mg/d) Female (mg/d)
3-8 years 140-700 140-700
9-12 years 300-1300 300-1300
13-17 years 500-2300 400-1600
18-50 years 1000-2500 700-1600
51-80 years 800-2100 500-1400
81 years and older 600-2000 400-1300

 
  Homovanillic Acid - per 24h 18 years and older: 0.0-15.0 mg/d
  Vanillylmandelic Acid - per 24h 18 years and older:  0.0-7.0 mg/d
  Vanillylmandelic Acid - ratio to CRT
Age mg/g CRT
0-2 years 0-27
3-5 years 0-13
6-17 years 0-9
18 years and older 0-6

 
  Homovanillic Acid - ratio to CRT
Age mg/g CRT
0-2 years 0-42
3-5 years 0-22
6-17 years 0-15
18 years and older 0-8

 

Vanillylmandelic acid (VMA) and homovanillic acid (HVA) results are expressed as a ratio to creatinine excretion (mg/g CRT). No reference interval is available for results reported in units of mg/L. Slight or moderate increases in catecholamine metabolites may be due to extreme anxiety, essential hypertension, intense physical exercise, or drug interactions. Significant increase of one or more catecholamine metabolites (several times the upper reference limit) is associated with an increased probability of a secreting neuroendocrine tumor.

Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.