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HelpTest Code LAB2030 Immunoglobulin D (IgD), Serum
Additional Codes
IGD
Useful For
Providing information on the humoral immune status
Identifying an IgD monoclonal gammopathy
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumOrdering Guidance
To distinguish between polyclonal and monoclonal IgD, order PEISO / Protein Electrophoresis and Isotype, Serum.
Specimen Required
Supplies: Sarstedt 5 mL Aliquot Tube (T914)
Patient Preparation: Fasting preferred but not required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 21 days |
Reference Values
≤10 mg/dL
Day(s) Performed
Monday through Friday
CPT Code Information
82784
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| IGD | Immunoglobulin D (IgD), S | 2460-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| IGD | Immunoglobulin D (IgD), S | 2460-4 |
Interpretation
The physiologic significance of serum IgD concentration is unclear and in many normal persons serum IgD is undetectable.
Increased concentrations may be due to polyclonal (reactive) or monoclonal plasma cell proliferative processes.
A monoclonal IgD protein is present in 1% of patients with myeloma. Monoclonal IgD proteins are often in low concentrations and do not have a quantifiable monoclonal protein on serum protein electrophoresis. However, the presence of an IgD monoclonal protein is almost always indicative of a malignant plasma cell disorder such as multiple myeloma or primary amyloidosis.
Method Description
The determination of the soluble antigen concentration by turbidimetric methods involves the reaction with specific anti-serum to form insoluble complexes. When light is passed through the suspension formed a portion of the light is transmitted and focused onto a photodiode by an optical lens system. The amount of transmitted light is indirectly proportional to the specific protein concentration in the test sample. Concentrations are automatically calculated by reference to a calibrations curve stored within the instrument.(Package insert: Optilite IgD Kit. The Binding Site Group, Ltd; 08/2018)
Report Available
1 to 3 daysSpecimen Retention Time
14 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
| Heat-activated specimen | Reject |
Method Name
Turbidimetry