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Test Code LAB1133 Lysozyme (Muramidase), Plasma

Additional Codes

MURA


Specimen Required


Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions:

1. Centrifuge and aliquot plasma into a plastic vial within 2 hours of collection.

2. Freeze immediately after transferring.


Secondary ID

607462

Useful For

As a screening test for ocular sarcoidosis

 

Confirming marked increases in the granulocyte or monocyte pools as in granulocytic or monocytic leukemias, myeloproliferative disorders, and malignant histiocytosis

 

Following the course of therapy in cases of chronic granulocytic or chronic monocytic leukemias

Method Name

Turbidimetric

Specimen Type

Plasma EDTA

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Frozen 21 days

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

≥12 months: 2.6-6.0 mcg/mL

Reference values have not been established for patients who are less than12 months of age.

Interpretation

Levels above 200 mcg/mL may be seen in acute nonlymphocytic leukemia (M2, M4, M5) or chronic granulocytic leukemias.

Method Description

The term lysozyme is derived from the ability of this enzyme to dissolve the walls of certain bacteria, including Micrococcus lysodeikticus. This organism is suspended in buffer, and the sample is added. The resulting decrease in turbidity is measured spectrophotometrically. The rate of clearing is a reflection of the concentration of the enzyme.(Litwack G: Photometric determination of lysozyme activity. Proc Soc Exp Biol Med. 1955;89(3):401-403)

Specimen Retention Time

7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

85549

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MURA Lysozyme (Muramidase), P 2589-0

 

Result ID Test Result Name Result LOINC Value
MURA Lysozyme (Muramidase), P 2589-0

Day(s) Performed

Monday through Friday

Report Available

2 to 5 days

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Benign Hematology Test Request (T755)

Hematopathology/Cytogenetics Test Request (T726)