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Test Code LAB111 Prostatic Acid Phosphatase, Serum

Additional Codes

PACP

Useful For

Aiding in predicting recurrence after radical prostatectomy for clinically localized prostate cancer

 

Following response to androgen ablation therapy, when used in conjunction with prostate-specific antigen

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Patient Preparation: For 12 hours before specimen collection, do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Collection Container/Tube: 

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  180 days

Reference Values

≤2.1 ng/mL

Day(s) Performed

Monday, Wednesday, Friday

CPT Code Information

84066

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PACP Prostatic Acid Phosphatase, S 20420-6

 

Result ID Test Result Name Result LOINC Value
PACP Prostatic Acid Phosphatase, S 20420-6

Interpretation

Prostatic acid phosphatase (PAP) levels above the reference range may indicate prostate cancer but can be due to many other factors, see Cautions.

 

A rise in PAP levels in patients with known prostate cancer can indicate tumor progression or recurrence. However, there is considerable intra-subject biological variability, limiting the usefulness of this test.

Method Description

The patient sample is added to a solid phase that is coated with a mouse monoclonal antibody specific for prostatic acid phosphatase (PAP). A goat-anti-PAP-alkaline phosphatase conjugate is added to form an antibody sandwich complex. Excess conjugate is removed by washing, and an adamantyl dioxetane phosphate substrate is added to produce chemiluminescence. Light emission is proportional to PAP concentration in the specimen.(Package insert: IMMULITE 2000 PAP. PIL2KPA-17. Siemens Healthcare; 03/15/2018)

Report Available

1 to 3 days

Specimen Retention Time

2 weeks

Reject Due To

Gross hemolysis Reject
Gross lipemia OK

Method Name

Automated Chemiluminescent Immunometric Assay

Secondary ID

8019