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HelpTest Code LAB1052 Manganese, Blood
Additional Codes
MNB
Useful For
Evaluation of central nervous system symptoms, similar to Parkinson disease, in manganese (Mn) miners and processors
Characterization of liver cirrhosis
Therapeutic monitoring in treatment of cirrhosis, parenteral nutrition-related Mn toxicity, and environmental exposure to Mn
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Whole bloodSpecimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies:
-Metal Free EDTA 3 mL Tube (T989)
-Metal Free B-D Tube (EDTA), 6 mL (T183)
Container/Tube:
Preferred: Royal blue-top BD vacutainer with EDTA blood collection tube (3 mL) (BD catalog no. 367777) (T989)
Acceptable: Royal blue-top BD Vacutainer Plus with EDTA blood collection tube (6 mL) (BD catalog no. 368381) (T183)
Specimen Volume: 0.3 mL
Collection Instructions:
1. See Metals Analysis Specimen Collection and Transport for complete instructions.
2. Send whole blood specimen in original tube. Do not aliquot.
Specimen Minimum Volume
0.2 mL
On-campus collections: Tube to 99 or deliver to University Extension Hospital Room EH318
Send in original tube, Refrigerated
Off-campus collections:
DO NOT SPIN!
Specimen to be stored/transported Refrigerated
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole blood | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Special Instructions
Reference Values
4.7-18.3 ng/mL
Day(s) Performed
Tuesday
CPT Code Information
83785
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MNB | Manganese, B | 5681-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 89120 | Manganese, B | 5681-2 |
Interpretation
Whole blood or serum concentrations in combination with brain magnetic resonance imaging scans and neurological assessment may be used to detect excessive exposure. Â Values between 1 and 2 times the upper limit of normal may be due to differences in hematocrit and normal biological variation and should be interpreted with caution before concluding that hypermanganesemia is contributing to the disease process. Values greater than twice the upper limit of normal correlate with disease. For longitudinal monitoring, sampling no more frequently than the half-life of the element (40 days) should be used.
Method Description
The metal of interest is analyzed by triple-quadrupole inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
Report Available
2 to 8 daysSpecimen Retention Time
14 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Triple-Quadrupole Inductively Coupled Plasma-Mass Spectrometry (ICP-MS/MS)