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HelpTest Code LAB1000 IgG4, Immunoglobulin Subclasses, Serum
Additional Codes
IGGS4
Useful For
Supporting the diagnosis of IgG4-related disease
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumOrdering Guidance
This test only quantitates the IgG4 protein. If quantitation of all IgG subclass types is desired, order IGGS / IgG Subclasses, Serum.
Specimen Required
Patient Preparation: Fasting preferred but not required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Ambient | 14 days | ||
| Frozen | 14 days |
Reference Values
0-<5 months: ≤19.8 mg/dL
5-<9 months: ≤20.8 mg/dL
9-<15 months: ≤22.0 mg/dL
15-<24 months: ≤23.0 mg/dL
2-<4 years: ≤49.1 mg/dL
4-<7 years: ≤81.9 mg/dL
7-<10 years: 1.0-108.7 mg/dL
10-<13 years: 1.0-121.9 mg/dL
13-<16 years: ≤121.7 mg/dL
16-<18 years: ≤111.0 mg/dL
≥18 years: 2.4-121.0 mg/dL
Day(s) Performed
Monday through Friday
CPT Code Information
82787
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| IGGS4 | IgG4, Ig Subclasses | 2469-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| IGGS4 | IgG4, Ig Subclasses | 2469-5 |
Interpretation
Elevated concentration of IgG4 is consistent with, but not diagnostic of, IgG4-related disease.
Method Description
The determination of the soluble antigen concentration by turbidimetric methods involves the reaction with specific antiserum to form insoluble complexes. When light is passed through the suspension formed a portion of the light is transmitted and focused onto a photodiode by an optical lens system. The amount of transmitted light is indirectly proportional to the specific protein concentration in the test sample.
Concentrations are automatically calculated by reference to a calibrations curve stored within the instrument.(Package inserts: Optilite IgG4. The Binding Site Group, Ltd: ver.23, 07/2019)
Report Available
1 to 2 daysSpecimen Retention Time
14 daysReject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
Method Name
Turbidimetry