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Test Code FERR1 Ferritin, Serum


Specimen Required


Patient Preparation:  For 12 hours before specimen collection, patient should not take multivitamins or dietary supplements (eg, hair, skin, and nail supplements) containing biotin (vitamin B7).

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container Tube: Plastic vial

Specimen Volume: 0.6 mL

Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.


Secondary ID

619953

Useful For

Aiding in the diagnosis of iron deficiency and iron overload conditions

 

Differentiating iron deficiency anemia and anemia of chronic disease

Method Name

Electrochemiluminescence Immunoassay

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  365 days
  Ambient  24 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus Reject

Reference Values

Males:

0 days-4 weeks: 150-973 mcg/L

5 weeks-5 months: 9-580 mcg/L

6 months-9 years: 6-111 mcg/L

10-17 years: 15-201 mcg/L

≥18 years: 31-409 mcg/L

 

Females:

0 days-4 weeks: 150-973 mcg/L

5 weeks-5 months: 9-580 mcg/L

6 months-17 years: 8-115 mcg/L

18-50 years: 6-175 mcg/L

≥51 years: 11-328 mcg/L

Interpretation

Hypoferritinemia is associated with increased risk for developing iron deficiency where iron deficiency is sufficient to reduce erythropoiesis causing hemoglobin concentrations to fall. Latent iron deficiency occurs when serum ferritin is low without low hemoglobin.

 

Hyperferritinemia is associated with iron overload conditions including hereditary hemochromatosis where concentrations may exceed 1000 mcg/L. Non-iron overload hyperferritinemia may be caused by common liver disorders, neoplasms, acute or chronic inflammation, and hereditary hyperferritinemia-cataract syndrome.

 

For more information about hereditary hemochromatosis testing, see Hereditary Hemochromatosis Algorithm.

Method Description

The Roche ferritin method employs monoclonal antibodies specifically directed against ferritin. A biotinylated monoclonal antibody and a second monoclonal antibody labeled with a ruthenium complex react to form a sandwich complex. After the addition of streptavidin-coated microparticles, the complex becomes bound to the solid phase via interaction of biotin and streptavidin. The reaction mixture is aspirated into the measuring cell where the microparticles are magnetically captured onto the surface of the electrode. Application of a voltage to the electrode then induces chemiluminescent emission, which is measured by a photo multiplier.(Package insert: Elecsys Ferritin. Roche Diagnostics; V2 10/2022)

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days

Specimen Retention Time

7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82728

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FERR1 Ferritin, S 20567-4

 

Result ID Test Result Name Result LOINC Value
FERR1 Ferritin, S 20567-4

Testing Algorithm

For more information see Hereditary Hemochromatosis Algorithm.