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HelpTest Code AFOLR Folate Receptor Alpha (FOLR1), Semi-Quantitative Immunohistochemistry, Manual
Ordering Guidance
This test may be utilized for all types of ovarian cancers.
Shipping Instructions
Attach the green "Attention Pathology" address label (T498) to the outside of the transport container before putting into the courier mailer.
Necessary Information
A pathology/diagnostic report and a brief history are required.
Specimen Required
Specimen Type: Tissue
Source: Ovarian tumor
Supplies: Pathology Packaging Kit (T554)
Collection Instructions: Formalin-fixed, paraffin-embedded tissue block; or 3 unstained glass, "positively charged" slides with 4-microns formalin-fixed, paraffin-embedded tissue
Additional Information: One slide will be stained with hematoxylin and eosin and returned.
Secondary ID
620731Useful For
Diagnosis of epithelial ovarian cancer that may be eligible for treatment with an anti-folate receptor 1 protein antibody
Method Name
Immunohistochemistry (IHC)
Specimen Type
SpecialSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Special | Ambient (preferred) | ||
| Refrigerated | |||
Reject Due To
| Wet/frozen tissue Decalcified paraffin embedded tissue Cytology smears Non-formalin fixed tissue including alcohol-formalin-acetic acid (AFA), 95% ethanol, PREFER fixatives or Zinc formalin Nonparaffin embedded tissue Noncharged slides ProbeOn slides |
Reject |
Reference Values
An interpretive report will be provided.
Interpretation
Folate receptor 1 protein (FOLR1) is a biomarker that, when positive (at least moderate membranous staining) in greater than or equal to 75% of tumor cells, predicts response to treatment with Elahere (mirvetuximab soravtansine) and has been approved for epithelial ovarian, fallopian tube, or primary peritoneal cancer.(1)
This result should be interpreted in the appropriate clinical context.
Method Description
Immunohistochemistry on sections of paraffin-embedded tissue.(Unpublished Mayo method)
Day(s) Performed
Monday through Friday
Report Available
5 to 7 daysSpecimen Retention Time
Until reportedPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
88360
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| AFOLR | FOLR1, SemiQuant IHC, Manual | 105010-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 620732 | Interpretation | 50595-8 |
| 621015 | Participated in the Interpretation | No LOINC Needed |
| 621016 | Report electronically signed by | 19139-5 |
| 621017 | Material Received | 81178-6 |
| 621018 | Disclaimer | 62364-5 |
| 621019 | Case Number | 80398-1 |
Forms
If not ordering electronically, complete, print, and send an Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.