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HelpTest Code SFIG LAB9766 Cerebrospinal Fluid IgG Index Profile, Serum and Spinal Fluid
Additional Codes
SFIG
LAB9766
IGG Synthesis
IGG INDEX
Specimen Required
Both serum and spinal fluid are required. Spinal fluid must be obtained within 7 days of serum collection.
Two individual serum samples are required.
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: 2 Plastic vials
Specimen Volume: 2 mL in 2 plastic vials, each vial containing 1 mL
Collection Instructions: Centrifuge and aliquot serum into 2 plastic vials within 2 hours of collection.
Specimen Type: Spinal fluid
Container/Tube: Sterile vial
Specimen Volume: 1 mL
Collection Instructions: Label specimen as SFINC.
Secondary ID
610783IGG INDEX
Useful For
Aiding in the diagnosis of multiple sclerosis and other central nervous system inflammatory conditions
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SFINC | IgG Index, CSF | No | Yes |
| SFIGS | IgG, S | No | Yes |
| ALBS1 | Albumin, S | Yes, (order ALB) | Yes |
Method Name
SFINC, SFIGS: Nephelometry
ALBS1: Photometric
Specimen Type
CSFSerum
Specimen Minimum Volume
Serum 1 mL in 2 plastic vials, each vial containing 0.5 mL
Spinal fluid: 0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 14 days | ||
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 28 days | ||
| Ambient | 7 days |
Reject Due To
| Criteria apply to serum specimens only. For CSF specimens, the criteria are not applicable. | |
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reference Values
CSF index: 0.00-0.85
CSF IgG: 0.0-8.1 mg/dL
CSF albumin: 0.0-27.0 mg/dL
Serum IgG
0-4 months: 100-334 mg/dL
5-8 months: 164-588 mg/dL
9-14 months: 246-904 mg/dL
15-23 months: 313-1,170 mg/dL
2-3 years: 295-1,156 mg/dL
4-6 years: 386-1,470 mg/dL
7-9 years: 462-1,682 mg/dL
10-12 years: 503-1,719 mg/dL
13-15 years: 509-1,580 mg/dL
16-17 years: 487-1,327 mg/dL
≥18 years: 767-1,590 mg/dL
Serum albumin
≥12 months: 3,500-5,000 mg/dL
Reference values have not been established for patients who are <12 months of age.
CSF IgG/albumin: 0.00-0.21
Serum IgG/albumin: 0.0-0.4
CSF IgG synthesis rate: 0-12 mg/24 hours
Interpretation
Cerebrospinal fluid (CSF) IgG synthesis rate indicates the rate of increase in the daily CSF production of IgG in milligrams per day. A result greater than 12 mg/24h is elevated.
A CSF index greater than 0.85 is elevated and indicative of increased synthesis of IgG.
Method Description
CSF IgG and albumin, and Serum IgG:
The cerebrospinal fluid (CSF) IgG and albumin, and serum IgG are determined by immunonephelometry. The CSF IgG index and synthesis rate are calculated and reported.(Instruction manual: Siemens BN II Nephelometer Operations. Siemens, Inc.; Version 2.3, 2008; Addendum to the Instruction Manual 2.3, 08/2017)
Serum albumin:
The dye, bromcresol green (BCG), is added to serum in an acid buffer. The color intensity of the blue-green albumin-BCG complex is directly proportional to the albumin concentration and is determined photometrically.(Package insert: Roche Albumin reagent. Roche Diagnostics; 03/2015)
Day(s) Performed
Monday through Friday
Report Available
2 to 5 daysSpecimen Retention Time
See Individual Test IDsPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82040
82042
82784 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SFIG | CSF IgG Index Profile | 14116-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| INDEX | IgG Index, CSF | 14117-6 |
| ALB_S | Albumin, S | 1751-7 |
| IGG_S | IgG, S | 2465-3 |
| AIGAS | IgG/Albumin, S | 6782-7 |
| IGG_C | IgG, CSF | 2464-6 |
| ALB_C | Albumin, CSF | 1746-7 |
| AIGAC | IgG/Albumin, CSF | 2470-3 |
| SRATE | Synthesis Rate, CSF | 14116-8 |