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Test Code LAB703 Ceruloplasmin

Additional Codes:

CERULO

Collection:

Specimen: Blood

Container: Serum Separator or Plain Red Top Tube

Volume: 4 mL; Minimum 2 mL

Pediatric Collection:

Two Gold or Red microtainers filled to 600 uL.

Storage Instructions:

Serum should be separated from red cells when stored or shipped. Specimens that cannot be tested immediately can be refrigerated up to 3 days. Freeze specimens for extended storage.

Turnaround Time (TAT):

Reported same day as performed.

Test Availability:

Test performed Monday, Wednesday, Thursday.

Performing Laboratory Section:

Special Chemistry / UMC Main Laboratory

Send To:

UMC MAIN LABORATORY Specimen Receiving – EH319 Hospital Extension

Reference Interval:

20 – 60 mg/dL

Interpretive Data:

Effective October 26, 2015, serum ceruloplasmin is measured by an immunoturbidimetric assay (Optilite, The Binding Site). Results by other assays should not be used interchangeably due to differences in analytical methods. Ceruloplasmin is synthesized in the liver and has a major role in copper metabolism, carrying approximately 95% of the total copper in serum.  Decreased levels of ceruloplasmin can be caused by hereditary disorders of copper metabolism, for example; inability to transport oxidized copper from the gastrointestinal epithelium into the circulation (as in Menkes disease), or the inability to insert copper into the developing ceruloplasmin molecule (as in Wilson's disease). Dietary copper insufficiency, including malabsorption, also reduces serum ceruloplasmin concentrations. Serum ceruloplasmin concentrations can increase as a result of acute-phase reactions, pregnancy or use of oral contraceptives.