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HelpTest Code LAB2662 Everolimus
Additional Codes:
EVERO
Collection:
Specimen: Blood
Container: Lavender Top Tube
Volume: 2 mL; Minimum 0.5 mL
Pediatric Collection:
One Lavender microtainer filled to 500 uL.
Storage Instructions:
Send specimen to Lab immediately after collection or refrigerate. Specimen must be shipped by overnight delivery.
Turnaround Time (TAT):
Monday – Friday: Specimen must be in lab by 1:00 PM for same day results. Saturday and Sunday samples must be in lab by 10:30am for same day results.
Test Availability:
Daily
Assay:
0.2 mL Whole blood
Performing Laboratory Section:
Special Chemistry / UMC Main Laboratory
Send To:
UMC MAIN LABORATORY Specimen Receiving – EH319 Hospital Extension
Reference Interval:
| Everolimus | ||
|---|---|---|
| Organ | 0 - 3 months of age (ng/mL) |
> 3 months |
| Kidney | 4 - 12 | 2 - 8 |
| Liver | 4 - 12 | 2 - 8 |
| Heart | 4 - 14 | 2 - 10 |
| Lung | 4 - 14 | 2 - 10 |
| Organ | Everolimus (ng/mL) reference range when given in combination with Tacrolimus or Cyclosporine | |
| Kidney | 3 - 8 | |
| Liver | 3 - 8 | |
| Heart | 3 - 8 | |
| Lung | 3 - 8 | |
Interpretive Data:
Everolimus marketed as Zortress is FDA approved for prophylaxis of organ rejection in adult patients receiving a kidney transplant. The suggested therapeutic range for pre-transplant prophylaxis is 3-8 ng/mL, which is based on a predose (trough) specimen in patients also receiving cyclosporine.
Everolimus marketed as Afinitor is FDA approved for the treatment of renal cell carcinoma and for the treatment of subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis (TS) in patients who are not candidates for curative surgical resection. The suggested therapeutic range for treatment of SEGA is 5-10 ng/mL, which is based on a predose (trough) specimen.