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HelpTest Code LAB2243 Kappa/Lambda Quantitative Free Light Chains with Ratio, Serum
Additional Codes:
KAP/LAM F
Collection:
Specimen: Blood
Container: Serum Separator or Plain Red Top Tube
Volume: 4 mL; Minimum 2 mL
Pediatric Collection:
Two Gold or Red microtainers filled to 600 uL.
Storage Instructions:
Serum should be separated from red cells when stored or shipped. Specimens that cannot be tested immediately can be refrigerated up to 21 days. Freeze specimens for extended storage.
Turnaround Time (TAT):
Reported same day as performed.
Test Availability:
Test performed Monday, Wednesday, Thursday.
Performing Laboratory Section:
Special Chemistry / UMC Main Laboratory
Send To:
UMC MAIN LABORATORY Specimen Receiving – EH319 Hospital Extension
Reference Interval:
Kappa Free: 0.33 - 1.94 mg/dL
Lambda Free: 0.57 - 2.63 mg/dL
Kappa/Lambda Ratio: 0.26 - 1.65
Interpretive Data:
Serum kappa and lambda free light chains (FLC) are measured by an immunoturbidimetric assay (Optilite, The Binding Site). Results by other assays should not be used interchangeably due to differences in analytical methods. Elevated serum levels of monoclonal free light chains are associated with malignant plasma cell proliferation (e.g. multiple myeloma), AL amyloidosis and light chain deposition disease. Raised serum levels of polyclonal FLC may be associated with autoimmune diseases such as SLE. Elevated kappa and lambda (K/L) FLC may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance. A specific increase in free kappa/lambda light chain ratio must be demonstrated for diagnostic purposes.